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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
EXPLORING UNIQUE FEATURES OF THE MITOCHONDRIAL GENOME OF CANDIDA SUBHASHII: INSIGHTS FROM COMPREHENSIVE COMPARATIVE ANALYSIS
Author
Dr. Vaisakhi K S
Email
keyword
Candida subhashii, Mitochondrial genome, Linear DNA molecules, Invertrons, Comparative genomics.
Abstract
This study focused on comprehensive comparative analysis of fungal mitochondrial genomes, focusing on Candida subhashii, and sequenced its mitochondrial genome. Our investigation revealed several intriguing features. Firstly, the mitochondrial dsDNA molecules were observed to possess a linear shape with a consistent size of 29,795 bp, and notably, they exhibited uniform length of 828 bp. Moreover, a relatively high proportion (52.7%) of guanine and cytosine content was identified within the genome region. Remarkably, the absence of introns within the coding sequences rendered the genome notably compact. Furthermore, examination of 59 linear molecules unveiled the presence of long inverted repeats at their termini, which were covalently bound with a protein. These repeats bear resemblance to telomeres in telomere-like DNA genomes and are speculated to initiate DNA synthesis in certain linear viral or plasmid DNA genomes, known as invertrons. Notably, Candida subhashii also harbors homologs of a polymerase from the family B and an unidentified protein, alongside genes found in other pathogenic Candida species. Our analysis suggests a scenario of recombination between an ancestral mitochondrial genome, potentially circular in nature, and one resembling an invertron, leading to the emergence of elements akin to invertrons. Additionally, the DNA polymerase genes identified in this genome architecture share similarities with those observed in mitochondrial plasmids
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