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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
IMPACT OF NALBUPHINE ON MATERNAL AND NEONATAL OUTCOMES IN ELECTIVE CESAREAN SECTIONS: A RANDOMIZED CONTROLLED TRIAL
Author
Dr. Tirmanwar Amar Govind Rao
Email
keyword
Obstetric analgesia, Anesthesia, Cesarean section, Nalbuphine
Abstract
In this study, the impact of nalbuphine on anesthesia quality, maternal stress response, and neonatal outcomes before general anesthesia induction for cesarean sections was investigated. Two groups of 120 women scheduled for elective cesarean sections were administered either normal saline-diluted nalbuphine 0.2 mg/kg or a placebo. Throughout induction, surgery, and recovery, heart rate and blood pressure were monitored. Neonatal outcomes, including APGAR score, time to sustain respiration, and umbilical cord blood gas analysis, were assessed. Mothers who received nalbuphine exhibited significantly lower heart rate increases during surgery compared to intubated mothers, although differences were not significant postdelivery. Mean arterial blood pressure (MABP) rose during intubation and surgery in the nalbuphine group compared to controls but normalized post-delivery. Nalbuphine-administered neonates had lower APGAR scores at one minute but reached scores of 9-10 by five minutes. They also took longer to achieve sustained respiration compared to controls, with comparable umbilical cord blood gas results between groups. Neonates did not require opioid antagonists or endotracheal intubation. Overall, nalbuphine reduced maternal stress during anesthesia and surgery but was associated with lower APGAR scores post-delivery. Monitoring and resuscitation by pediatricians were necessary due to nalbuphine's effects on neonatal outcomes.
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