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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
EFFECT OF EYE OINTMENT ON OCULAR ABERRATION: A PROSPECTIVE COMPARATIVE STUDY
Author
Dr. Chigurupathi Haasitha
Email
Chigurupathi@gmail.com
keyword
Eye, Ointment, Ofloxacin, Volunteers
Abstract
An eye ointment was investigated for its influence on ocular aberration. Analyses were conducted using a prospective, comparative design. Using 10 normal volunteers, ocular aberration was measured before and after administration ofloxacin eye ointment for five minutes, 30 minutes, one hour, two hours, three hours, and twelve hours. A total of four higher-order aberrations (HOAs) were measured sequentially over 10 seconds, and their root mean square (RMS) was calculated. The fluctuations in the total HOAs over 10 seconds were used to calculate a fluctuation index (FI). In a study using gel-forming ophthalmic solution containing timolol maleate, we compared the results with other patients. The second-order RMS was not significantly altered by ointment administration. As a result of the study, significantly different HOAs were observed in third-, fourth-, and total higher-order RMS during the study period. A significant increase in RMS was observed 5 minutes after administration of each component of the HOA. Five minutes after administration, FI increased significantly, but SI remained unchanged. A Mann-Whitney U-test showed that HOAs and FI values after 6 h had significantly higher values compared with the gel-forming solution group. A significant increase and oscillation of HOAs occurs when eye ointment is administered. It is important to note that these changes were more pronounced than those observed after several hours' instillation or gel-forming ophthalmic solution.
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