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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
TO STUDY IMMUNOLOGICAL AND HORMONAL ALTERATIONS IN ADULTS SUFFERING FROM DEPRESSION
Author
Avinash Chowdary K1, Perol Yadav Meruva
Email
drpebyreddy@gmail.com
keyword
Depression, Hormonal Alterations, Immunological Changes, Cross-Sectional Study, Psychiatric Morbidity
Abstract
Depression is a widespread mental health concern with multifaceted etiological factors, including potential hormonal and immunological alterations. This cross-sectional study aims to investigate the relationships between depression and markers of hormonal and immunological status in adults. A total of 146 adults, aged 18 to 65, were recruited for this study, comprising 73 individuals diagnosed with depression and 73 age-matched healthy controls. Hormonal assessments included thyroid-stimulating hormone (TSH), and prolactin, while immunological parameters encompassed C-reactive protein (CRP) and Fasting blood glucose. The severity of depression was evaluated using standardized psychometric tools. Preliminary findings reveal significant alterations in TSH and prolactin were observed in the depressed group compared to controls (p<0.01), suggesting perturbations in thyroid function and reproductive hormones. Immunological assessments demonstrated elevated CRP levels in depressed individuals (p<0.001), indicative of an inflammatory response associated with depression.This cross-sectional study provides initial insights into the hormonal and immunological alterations associated with depression in adults. The observed dysregulations in TSH, prolactin, FBS and CRP emphasize the intricate interplay between the endocrine and immune systems in depressive disorders. Further exploration of these associations may contribute to a better understanding of the pathophysiological mechanisms underlying depression and facilitate the development of targeted therapeutic interventions
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