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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
PROPHYLACTIC USE OF GRANISETRON FOR PREVENTION OF NAUSEA AND VOMITING DURING CESAREAN DELIVERIES: A RANDOMIZED CONTROLLED TRIAL
Author
Dr Satyanarayana Yanda
Email
keyword
Granisetron, Nausea, Vomiting, Cesarean delivery, Spinal anesthesia
Abstract
In this study, we investigated the efficacy of granisetron, a 5HT3 receptor antagonist, in preventing nausea and vomiting during cesarean deliveries performed under spinal anesthesia. A total of 160 pregnant women received either intravenous granisetron (40 mg/kg) or placebo after umbilical cord clamping (n = 80 each). Following spinal anesthesia, patients were monitored for nausea, vomiting, and adverse events for 24 hours. Granisetron achieved a complete response in 80% of patients immediately after spinal anesthesia, compared to 45% with placebo. From 4 to 24 hours post-anesthesia, the corresponding rates were 83.5% and 55% (P < 0.06). Adverse events did not significantly differ between the groups. Granisetron demonstrates efficacy in preventing emetic episodes during spinal anesthesia for cesarean delivery when administered prophylactically
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