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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
A POLYMER COATED WITH ZINC OXIDE DRUG: A POTENTIAL SOLUTION FOR INFECTION-RESISTANT MEDICAL DEVICES
Author
Dr. Rudra Gaitham Naresh*, Dr. Reddi Naresh, Dr. Yugandhar Reddy
Email
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Medical Device Coating, Nanoparticles of Zinc Oxide, Antimicrobial, Nitric Oxide
Abstract
The emergence of antibiotic resistance indicates the importance of creating infection-resistant materials. In this study, the nitric oxide (NO)-releasing polymer is coated with zinc oxide nanoparticles (ZnO-NP) to boost NO release and match the endogenous NO flux (0.55 - 4010 mol cm2 min1). The ZnO-NP is utilized as a catalyst and has the added benefit of acting as an antibacterial agent when combined with NO. The ZnO-NP topcoat is applied to a CarboSil polycarbonate-based polyurethane that contains S-nitroso-N-acetylpenicillamine, a blended NO donor (SNAP). This sample, SNAP-ZnO, kept NO release over 0.5 1010 mol cm2 min1 for 14 days, but samples containing simply SNAP fell below physiological levels after 24 hours. The ZnO-NP topcoat boosted NO release and reduced the amount of SNAP leached by 55% over the course of seven days. The catalyst's lifespan within the material was determined by ICP-MS analyses, which demonstrated very little Zn ion release into the environment. In contrast to samples that did not contain NO-release, the SNAP-ZnO films had a 99.03 percent killing efficiency against Staphylococcus aureus and an 87.62 percent killing efficiency against Pseudomonas aeruginosa. Cell viability did not differ significantly between controls and SNAP-ZnO material in a cytotoxicity study performed on mouse fibroblast 3T3 cells, suggesting there was no harm to mammalian cells. A metal ion catalyst used in conjunction with a NO-releasing polymer proved to be highly effective for enhancing NO-release kinetics and antibacterial activity for device coatings
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