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American Journal of Oral Medicine and Radiology

Volume 5, Issue 2, 2018
Mcmed International
American Journal of Oral Medicine and Radiology
Issn
XXX-XXXX (Print), 2394 - 7721 (Online)
Frequency
bi-annual
Email
editorajomr@mcmed.us
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Abstract
Title
GENETIC POLYMORPHISMS IN CYTOCHROME P450 ENZYMES AND CHEMOTHERAPY RESPONSE IN BREAST CANCER
Author
Dr. Chandrakala kothapalle, Dr. Kondareddy Narsappagari Srilakshmi
Email
keyword
Breast, Cancer, Women, Cytochrome P450, Gene, Neo-adjuvant
Abstract
This investigation aimed to elucidate the influence of genetic polymorphisms within cytochrome P450 enzymes, namely CYP3A4, CYP3A5, CYP2B6, CYP2C8, CYP2C9, and CYP2C19, on the clinical response to neoadjuvant chemotherapy in 198 breast cancer patients. Utilizing RLFP analysis, functionally significant variants were identified. Results demonstrated a significant correlation between the CYP2C92 polymorphism and chemotherapy resistance (OR = 4.64; 95% CI = 1.01 – 20.91). Notably, CYP2C92 heterozygotes displayed heightened resistance, particularly in women with nodal forms of breast cancer and a hereditary cancer burden (OR = 15.50; 95% CI = 1.08 – 826.12), suggesting potential combined effects. However, no significant associations were observed between chemotherapy resistance and other examined genotypes, as well as combined clinical and tumor-related parameters. In conclusion, the presence of the CYP2C9*2 polymorphism strongly correlates with neoadjuvant chemotherapy resistance within this study's breast cancer patient population
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