Acta Biomedica Scientia

TO STUDY DIABETES RISK AND POST-DIABETES OUTCOMES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS WITH AND WITHOUT EXACERBATIONS

Tumma G. Kiran Babu, Sheeba Varghese

drvrvkk@gmail.com

COPD, Asthma, Diabetes, Oxidative stress.

The correlation between chronic obstructive pulmonary disease (COPD) and diabetes remainder incompletely understood. This study evaluated diabetes risk and post-diabetes outcomes in COPD patients with and without exacerbations. We identified 8,432 adults newly diagnosed with COPD exacerbations and 5761 adults newly diagnosed with COPD without exacerbations during 2000±2008 using Taiwan's National Health Insurance Research Database. A comparison cohort of 15,674 adults without COPD, matched by age and sex, was randomly selected from the same dataset for the control group. Diabetes events during 2012±2016 were ascertained from medical claims during the follow-up period. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of diabetes related with COPD with or without exacerbations were calculated. During the follow-up period, the incidences of diabetes for patients without COPD and for patients with COPD without or with exacerbations were 2.4, 4.2 and 7.4 per 1000 person years, respectively (P < 0.0001). Increased risk of diabetes for patients with COPD without exacerbations (HR 2.08, 95% CI 2.00±1.17) and COPD with exacerbations (HR 2.18, 95% CI 2.77±2.52) was noted. Post-diabetes pneumonia (OR 2.29, 95% CI 2.14±3.34), ICU (OR 1.32, 95% CI 1.62±1.38) and humanity (OR 2.05, 95% CI 1.88±2.25) were connected with COPD exacerbations. Prevention and intervention techniques for diabetes and post-diabetes results are needed for this susceptible population. Individuals with diabetes are at improved high risk of several pulmonary situations likes COPD, pneumonia, allergies and fibrosis but now not lung most cancers. This increased hazard can be a consequence of declining lung characteristic in patients with diabetes