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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
TO EVALUATE THE FORMULAE WITH 24 HOUR URINE CREATININE CLEARANCE IN ESTIMATING GLOMERULAR FILTRATION RATE IN CRITICALLY ILL PATIENTS
Author
Abishek C1, Nithish Timothy R
Email
nithishent@gmail.com
keyword
GFR, intensive care, Cockcroft Gault formula, MDRD, Creatinine clearance
Abstract
Glomerular filtration rate is the most common variable used in the clinical practice for estimating the renal function. In this study, we compared the accuracy of Cockroft Gault formula and MDRD formula with the 24 hour urine creatinine clearance. The study is a cross sectional study conducted on 100 patients admitted to the ICU of Sri Lakshmi Narayana Institute of Medical sciences, Pondicherry. The mean glomerular filtration rate measured by 24 hours urine creatinine clearance was 44.75ml/min/1.73m2 (95% CI: 41.13 to 48.37). The mean glomerular rate calculated by Cockcroft-Gault formula was 56.48ml/min/1.73m2 (95%CI: 52.45 to 60.51) and by MDRD formula was 48.71ml/min/m2 (95% CI: 44.80 to 52.62), with p value <0.0001 for both the formulae. However both the formulas overestimate the GFR which in our study is 11.73ml/min for Cockcroft-Gault equation and 3.961ml/min for MDRD equation
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