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American Journal of Oral Medicine and Radiology

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Oral Medicine and Radiology
Issn
XXX-XXXX (Print), 2394 - 7721 (Online)
Frequency
bi-annual
Email
editorajomr@mcmed.us
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Abstract
Title
MICROBIAL PROFILE AND ANTIBIOTIC SENSITIVITY IN PRETERM PREMATURE RUPTURE OF MEMBRANES (PPROM) AMONG PREGNANT WOMEN: IMPLICATIONS FOR TREATMENT IN RESOURCE-LIMITED SETTINGS
Author
Anuradha V
Email
keyword
Preterm premature Membrane Rupture, Antibiotic Sensitivity Testing, Female genital tract, Microbiology, Preterm infants
Abstract
This study aimed to identify prevalent microbes in pregnant women with preterm premature rupture of membranes (PPROM) and assess their susceptibility to various antibiotics, with the goal of determining appropriate antibiotic treatment strategies in resource-limited settings. Endocervical swabs were collected from all participants, and microbiological examination was conducted to identify the prevalent microbes. Antibiotic susceptibility testing was performed using the Kirby-Bauer disk diffusion method. The results revealed that Streptococcus spp., Staphylococcus aureus, and Escherichia coli were significantly more prevalent in women with PPROM (P < 0.01). Among the tested antibiotics, cefixime, cefuroxime, and erythromycin demonstrated the highest sensitivity during pregnancy. Based on these findings, it is recommended that in the first 48 hours after the onset of PPROM in women, intravenous administration of antibiotics such as ampicillin-sulbactam, cefixime, cefuroxime, or erythromycin should be initiated, followed by oral administration. These antibiotics were found to be effective against the prevalent microbes associated with PPROM, suggesting their potential utility in managing this condition in resource-limited settings. This study provides valuable insights into the microbial profile and antibiotic susceptibility patterns in pregnant women with PPROM, offering guidance for clinicians in selecting appropriate antibiotic therapies tailored to the microbial profile observed in this population. Further research is warranted to validate these findings and optimize antibiotic treatment strategies for PPROM in diverse clinical settings
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