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American Journal of Oral Medicine and Radiology

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Oral Medicine and Radiology
Issn
XXX-XXXX (Print), 2394 - 7721 (Online)
Frequency
bi-annual
Email
editorajomr@mcmed.us
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Abstract
Title
EFFECTIVENESS AND TOLERABILITY OF BETAHISTINE IN IMPROVING QUALITY OF LIFE IN PATIENTS WITH PERIPHERAL VESTIBULAR VERTIGO
Author
Santhosh Kumar R
Email
Santhosh Kumar R@gmail.com
keyword
Dizziness, vertigo, anxiety, depression, betahistine, and depression
Abstract
A cohort study on 490 patients experiencing peripheral vestibular vertigo participated in an international postmarket surveillance study evaluating betahistine. Primary endpoints included the SF-36v2, the Hospital Anxiety and Depression Scale, and the Dizziness Handicap Index. The study revealed a significant 41-point improvement in the total Dizziness Handicap Index score, with statistically significant enhancements observed in each domain of the Dizziness Handicap Index scale. Betahistine therapy demonstrated notable improvements in anxiety and depression scores according to the Hospital Anxiety and Depression Scale, along with enhancements in both physical and mental components of SF-36v2. Within the safety population, only two suspected adverse drug reaction was reported. The study suggests that a daily dosage of 48 mg of betahistine is particularly effective in improving health-related quality of life measures among patients experiencing recurrent peripheral vestibular vertigo, and the drug was well-tolerated
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