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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
IMPACT OF HYPERCHOLESTEROLEMIA ON BONE HEALTH: INSIGHTS FROM A FOUR-MONTH FEEDING STUDY IN MICE
Author
Sudha Parimala S
Email
Sudha Parimala S@gmail.com
keyword
Hypercholesterolemia, Osteoporosis, Bone Health, Cholesterol Homeostasis, Micro-Computed Tomography, Osteoclastogenesis
Abstract
Studies have suggested a link between hypercholesterolemia and osteoporosis, but direct evidence on the impact of cholesterol homeostasis on bone health is limited. In a four-month feeding study with mice subjected to isocaloric high-fat and high-cholesterol diets, micro-computed tomography analysis revealed a significant decrease in bone mineral density, ranging from 60 to 90 mg/mL across different strains. Mechanical testing of femurs demonstrated bone loss, resulting in a reduction in failure load (up to 10%) and energy to failure. The study also highlighted hypercholesterolemia's role in promoting osteoclastogenesis. These findings underscore the connection between hypercholesterolemia and osteoporosis, providing insights for potential intervention strategies
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