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European journal of molecular biology and biochemistry

Volume 1, Issue 5, 2014
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
BLOOD GLUCOSE LOWERING EFFECT OF CATHARANTHUS ROSEUS IN ALLOXAN INDUCED DIABETIC RATS
Author
Palwasha Abbasi1, Sadia Tabassum Abbasi2, Sadia Kazi3, Haji Khan Khoharo*4, Mozna Talpur5, Shomail Siddiqui6
Email
drhajikhan786@gmail.com
keyword
Catharanthus roseus, Alloxan Rats, Sindh.
Abstract
To investigate the blood glucose lowering effect of catharanthusroseus in alloxan induced diabetic rats. Study Design: Analyticals and Experimental study. Place and Duration: Animal house of Isra University, Hyderabad, Sindh from May to Novermber 2013. Forty male Wistar albino rats were selected according to inclusion and exclusion criteria. Animals were kept in separate stainless steel cages at normal temperature, 12 hour darklight cycle and free access to chow and water. Rats were divided into four groups as; Group A: control (n=10), Group B: diabetic (alloxan treated control) (n=10), Group C: diabetics treated with Catharanthus roseus (n=10), Group D: diabetic treated with Glimepiride (n=10). Diabetes mellitus was induced by single intraperitoneal injection of Alloxan (Sigma Company) at the dose of 120mg/kg. Blood samples were taken on days 0, 7 and 14. Glimepiride was given orally at the dose of 0.1mg/kg and Catharanthus roseus at 125mg/kg. Data was analyzed on SPSS version 21.0. The continuous variables were analyzed by ANOVA and post Hoc Tukey-Cramer. The significant p-value was taken at ≤ 0.05. Significant differences were observed for blood glucose among groups on different days. The blood glucose was low in Catharanthus roseus compared with alloxan (p=0.001), however, it was more compared to glimepiride group (p=0.001). The finding suggests that Catharanthus roseus lowers blood glucose. The blood glucose lowering effect of Catharanthus roseus was inferior to glimepiride but it was observed. The present study concludes that the Catharanthus roseus shows blood glucose lowering effect in alloxan induced diabetic rat model.
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