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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
TO STUDY P16 INK4A STATUS AS A BIOMARKER FOR UTERINE CERVICAL NEOPLASMS IN INDIA PATIENTS
Author
Monica Kumbat
Email
drpebyreddy@gmail.com
keyword
Uterine cervical neoplasms, Human papilloma virus and p16
Abstract
Uterine cervical cancer is the most common cancer cause of death in the developing countries. Human papilloma virus (HPV) infection is the most important risk factor for uterineCervical neoplasms. HPV oncogene expression can be detected by cellular protein p16 (INK4a) using immunostaining and it may assist in improving the reproducibility of diagnoses in cervical dysplastic and reactive lesions. This study aims to observe the frequency and distribution of p16INK4a protein expression and relating it to different histological grades of uterine cervical neoplasms. Of the 608 cases of uterine cervical neoplasms diagnosed during the study period, 60 cases were selected randomly for p16INK4a expression by immunohistochemistry. It was observed that CIN1 constituted77% of the total intraepithelial neoplasms and squamous cell carcinoma is the most frequent type of malignancy accounting for 96%invasive tumors. P16ink4a immunoreactivity was positive in 100% of all cervical neoplasms included in the study (p<0.0001) and its intensity of staining, distribution increased with increasing grades of cervical neoplasms. This pattern of over expression demonstrates the potential use of p16 as a diagnostic marker for cervical squamous and glandular neoplastic lesions
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