Acta Biomedica Scientia

PREVALENCE OF MBL PRODUCING PSEUDOMONAS AERUGINOSA IN TERTIARY CARE HOSPITAL

Yamuna Devi V.R1*, Arunachala D Edukondalu

yaminielumalai2004@yahoo.com

Pseudomonas aeruginosa, Metallo-?-lactamase (MBL), Prevalence, Antibiotic resistance, Antibiotic sensitivity patterns, Multidrug-resistant organisms

Pseudomonas aeruginosa, a notorious nosocomial pathogen, exhibits intrinsic resistance to various antibiotics. The emergence of Metallo-?-lactamase (MBL) production in P. aeruginosa poses a serious threat to the efficacy of carbapenems, crucial antibiotics in treating severe infections. Tertiary care hospitals, due to their complexity and patient diversity, are potential reservoirs for multidrug-resistant organisms, making the investigation of MBL prevalence imperative for informed therapeutic interventions. This study aims to determine the prevalence of MBL-producing P. aeruginosa in a tertiary care hospital, elucidating the epidemiology, antibiotic sensitivity patterns, and potential implications for patient outcomes. Clinical isolates of P. aeruginosa will be collected seventy samples from diverse hospital wards over two months. The presence of MBL will be assessed using established phenotypic methods, and antibiotic sensitivity profiles will be determined. Statistical analyses will be employed to evaluate the prevalence rates and associations. The percentage and Mean ±SD were used to express the data. The study anticipates revealing the frequency of MBL production in P. aeruginosa isolates, providing insights into the distribution across hospital wards. Antibiotic sensitivity patterns will be elucidated, emphasizing the potential impact on therapeutic strategies. Understanding the prevalence of MBL-producing P. aeruginosa in a tertiary care hospital setting is crucial for optimizing antimicrobial stewardship and infection control measures. The findings of this study are anticipated to contribute valuable insights into the current landscape of antibiotic resistance, guiding evidence-based interventions to enhance patient care and minimize the spread of multidrug-resistant pathogens in healthcare settings