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American Journal of Oral Medicine and Radiology

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Oral Medicine and Radiology
Issn
XXX-XXXX (Print), 2394 - 7721 (Online)
Frequency
bi-annual
Email
editorajomr@mcmed.us
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Abstract
Title
EXPLORING GONADOTROPIN DOSAGE EFFECTS ON PREGNANCY OUTCOMES IN IN VITRO FERTILIZATION FOR POOR OVARIAN RESERVE: A COMPARATIVE STUDY OF MINIMUM-DOSE STIMULATION AND HIGH-DOSE STIMULATION PROTOCOLS
Author
Dr Dhaka Sushma Dilip
Email
Dr Dhaka Sushma Dilip@gmail.com
keyword
Minimum-dose stimulation, High-dose stimulation, Poor ovarian reserve, Gonadotropin-antagonist protocols, In vitro fertilization (IVF)
Abstract
This retrospective cohort study explores the efficacy of minimum-dose stimulation (MS) compared to high-dose stimulation (HS) in improving clinical pregnancy rates in patients with poor ovarian reserve (POR). The study compares gonadotropinantagonist protocols for MS and HS, considering antral follicle count (AFC) on days 2-3 and anti-Mullerian hormone (AMH) levels of 8 pmol/L as inclusion criteria. The MS protocol involves a daily oral administration of 2.5 mg letrozole for 5 days, starting on day 2, and 150 units of daily gonadotropins from the third day following letrozole. GnRH antagonists are introduced when the follicle diameter exceeds 14 mm. In the HS group, gonadotropins are administered at a dosage of over 300 IU daily during the antagonist cycle. The results indicate a significant increase in clinical pregnancy rates with the HS protocol (P = 0.007). Furthermore, there is a notable difference in live birth rates between the MS and HS groups (P = 0.034). The study suggests that lower gonadotropin dosages in the MS IVF protocol may lead to higher clinical pregnancy and live birth rates, particularly in poor responders
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