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American Journal of Biological and Pharmaceutical Research

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
GEOGRAPHICAL DISPARITIES IN ANTIBIOTIC SUSCEPTIBILITY PATTERNS OF UROPATHOGENS: A CROSS-SECTIONAL STUDY ON URINARY TRACT INFECTIONS
Author
Dr. Sushma Yadav B
Email
Dr. Sushma Yadav B@gmail.com
keyword
Urinary tract infections, Uropathogens, Antibiotic susceptibility, Microbial prevalence, Empirical antibiotic therapy
Abstract
This research delves into the diverse microbial infections affecting the urinary tract, encompassing urethral, kidney, and bladder infections. UTIs, prevalent across all age groups, pose significant mortality risks. While bacteria predominantly cause UTIs, the role of viruses, fungi, and parasites cannot be overlooked. The use of different antibiotics in community and hospital settings influences uropathogen prevalence. This study investigates potential disparities in antibiotic susceptibility patterns among uropathogens in rural and urban areas. Conducted as observational cross-sectional research, 690 clean-catch midstream urine samples from clinically suspected UTI cases were examined. A KirbyBauer disc diffusion method assessed antibiotic susceptibility, guided by CLSI protocols. UTIs exhibited a wide array of isolates, including Escherichia coli, Klebsiella spp., Enterococcus faecalis, Staphylococcus aureus, and Enterococcus niger. Given the variation in bacterial uropathogen prevalence and antibiotic sensitivity across locations and over time, accurate UTI diagnosis relies on clinical signs, symptoms, positive urine culture, and uropathogen-specific antibiotic susceptibility. Initiation of empirical antibiotic therapy without such knowledge may prolong disease, lead to complications, and contribute to multidrug resistance development
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