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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
COMPREHENSIVE ANALYSIS OF ANTIBIOTIC-RELATED ADVERSE DRUG REACTIONS IN A DIVERSE PATIENT COHORT
Author
Faheem Nawaz S. MD1, Venkateswaraiah
Email
drpebyreddy@gmail.com
keyword
Antibiotics, Adverse Drug Reactions (ADRs), Demographic Distribution, Severity Levels.
Abstract
This cross-sectional study examines antibiotic-related Adverse Drug Reactions (ADRs) in 250 individuals, aiming to elucidate demographics, distribution patterns, and severity levels associated with thesereactions.Patient information, including age, gender, and ADR details, was recorded in detail. The WHO's causation assessment categorized ADR certainty. Data analysis included breakdowns based on age groups, antibiotic classes, administration routes, and affected organ systems.The diverse cohort (132 males, 118 females) showed young adults (30-45 years) constituting 27%. Predominant ADR contributors were ?-lactams (32.8%), followed by sulfonamides, macrolides, and fluoroquinolones. Outpatient settings reported higher ADR incidence (84.8%) than indoor patients (15.2%). Oral antibacterials caused 89% of ADRs, with most (72%) within the first three days.The gastrointestinal tract (58.6%) was most affected, with prominent cutaneous presentations (33.3%), especially itching and rash. Hypersensitivity responses were notably associated with sulphonamides. ADR intensity categorization revealed 60.8% moderate, 35.6% mild and 4.4% severe ADRs.This study offers a comprehensive overview of antibiotic-related ADRs, emphasizing demographic distribution, causative agents, and clinical manifestations. Findings underscore the need for vigilant monitoring, particularly in outpatient settings, providing valuable insights for healthcare professionals managing and preventing antibiotic-related ADRs
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