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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
MITIGATING TARTRAZINE-INDUCED PATHOLOGICAL CHANGES IN THE PAROTID GLAND: A HISTOLOGICAL AND ULTRASTRUCTURAL INVESTIGATION WITH OMEGA-3 FATTY ACID INTERVENTION
Author
Dr Mahathi krothapalli, Dr Shruti Heda
Email
Shruti Heda@gmail.com
keyword
Corneal, Sensitivity, Mechanical, Chemical, Thermal.
Abstract
There is a wide variety of food additives that contain tartrazine. Different body organs can be adversely affected by it. The antioxidant, anti-apoptotic, and anti-inflammatory properties of omega-3 fatty acids are well documented. To determine whether omega-3-fatty acids protect the parotid gland against changes induced by tartrazine. A total of 21 albino rats were divided into three groups in this study. The control group received tartrazine at 320 mg/kg daily, the tartrazine-treated group received tartrazine at 320 mg/kg body weight daily, while the tartrazine and omega-3 treatment group received omega-3 daily at 300 mg/kg body weight, as well as tartrazine. Four weeks were spent treating the patient. A variety of light and electron microscopy techniques were used on parotid gland specimens, including hematoxylin and eosin, Sirius red stains, and caspase-3 immunofluorescence. There was an increase in darkly stained nuclei, as well as cytoplasmic vacuolations of parotid acini in the tartrazine-treated group. There is a significant difference in % between the control group and the group immunostained for caspase-3 and collagen fibers. Tartrazine-treated acinar cells showed irregular nuclei, dominant electronlucent granules, and dilated rough endoplasmic reticulum, as well as degenerative changes in ductal epithelium, according to ultrastructural analysis. Studying the structure of the parotid gland histologically and morphometrically revealed that omega-3 improved its structure. Tarrazine's structural effects on the parotid gland were ameliorated by omega-3 treatment.
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