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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
EXPLORING THE DYNAMICS OF NEUROPEPTIDE Y (NPY), SYMPATHETIC ACTIVITY, AND FEEDING BEHAVIOR IN EXPERIMENTAL TYPE 1 DIABETES: A FOCUS ON THE PARAVENTRICULAR NUCLEUS (PVN) OF THE HYPOTHALAMUS
Author
Dr Santosh Mohanlal Modani, Dr Apuroopa Kunireddy
Email
Kunireddy@gmail.com
keyword
A streptozotocin treatment increases sympathetic activity and feeding habits due to a decrease in NPY receptor expression
Abstract
NPY modulates sympathetic activity and feeding behavior by interacting with norepinephrine neurons. The level of NPY in the hypothalamus is correlated with sympathetic activity in diabetes, but little effort has been made to identify the relationship between NPY and sympathetic activity in experimental type 1 diabetes. The male Sprague Dawley rats were instilled with streptozotocin (65 mg/kg body weight) intravenously to induce diabetes. The animals were examined again after two weeks, four weeks, and eight weeks. Animals in the control group were only given citrate vehicle. For clarifying the modulatory effect of NPY at early stages of diabetes, the paraventricular nucleus (PVN) of the hypothalamus was microdialyzed. NPY levels jumped almost immediately after streptozotocin injection, while norepinephrine levels were not increased for 8 weeks after injection. Significant weight loss was observed in the animals. PVN feeding behavior and NPY levels are strongly correlated, based on these results. Following diabetes, NPY receptors may be down-regulated since NPY inhibits sympathetic activity. Animals did not gain weight despite higher norepinephrine levels indicating high sympathetic activity. Additionally, NPY is controversial because of its actions as a pleiotropic in relation to the behavioral aspects of feeding in these animals
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