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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
A STUDY ON BENZODIAZEPINES CLASS OF DRUG AND NONBARBITURATE CLASS OF DRUGS: SYNERGISTIC ANAESTHESIA EFFECTS AMONG CARDIO-VASCULAR PATIENTS
Author
Dr. Sai Baba S
Email
Sai Baba S@gmail.com
keyword
Midazolam, propofol, Cardiovascular effects
Abstract
By administering a small dose of midazolam during induction at the trachea, this study aims to reduce the amount of propofol administered and prevent cardiovascular changes. Elective surgery was performed on 40 patients over the age of 60. The general anaesthesia was provided by combining remifentanil with propofol or midazolam. Induction was performed with 0.9% NaCl 0.03 ml/kg, propofol 1.2 mg/kg, and remifentanil for group P (n = 20). Group MP (n = 20) received midazolam 0.03 mg/kg, propofol 0.8 mg/kg, and remifentanil to induce anaesthesia. The time to reach a bispectrality index score (BIS) was recorded at the time of loss of consciousness (LOC). Rocuronium 0.8 mg/kg was administered after LOC to induce tracheal intubation. We measured mean blood pressure (MBP) and heart rate three minutes after induction and before intubation as baseline values, and immediately after intubation. In groups P and MP, the mean blood pressure decreased significantly (P< 0.05) at 3 minutes after intubation. A significant difference was found between group MP and group P in MBP decreases before intubation, immediately after intubation, and three minutes after intubation (P < 0.05). In comparison with group P, MP reached LOC significantly faster (P < 0.05). Midazolam and propofol were co-administered during tracheal intubation and avoided a marked decrease in patient blood pressure during the procedure
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