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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
COMPARATIVE ANALYSIS OF CELECOXIB AND ACETAMINOPHEN PREMEDICATION FOR POSTOPERATIVE PAIN MANAGEMENT AND QUALITY OF LIFE ENHANCEMENT IN LOWER EXTREMITY SURGERY UNDER GENERAL ANESTHESIA
Author
Dr B Rajesh Naidu, Dr Amar Tirmanwar
Email
Tirmanwar@gmail.com
keyword
Pain, PONV, Acetaminophen, Celecoxib, Premedication, Postoperative
Abstract
In recent years, molecular and clinical research has focused on the concept of controlling pain after surgery. In a study comparing celecoxib and acetaminophen premedication with lower extremity surgery under general anesthesia, celecoxib and acetaminophen were used to alleviate postoperative pain. In this study, 80 patients undergoing lower limb surgery under general anesthesia were examined to determine if the procedure improves their quality of life. A 1000 milligrams of acetaminophen or 4000 milligrams of celecoxib were administered to the first and second groups, respectively, an hour before surgery. In both groups, pain and nausea severity were evaluated using visual analog scales (VAS). In the first hour after surgery, acetaminophen group had more postoperative pain intensity (5.46±1.17) compared with celecoxib group (4.31±1.32) (p<0.001). Both groups did not differ significantly during the rest of the study. Postoperative pain intensity in both groups was significantly different during the study (p=0.013) based on an analysis of variance with repeated observations. There was a significant difference in nausea intensity between the acetaminophen and celecoxib groups in the first hour after surgery (2.8±1.1 vs. 2.2±1.3, p<0.034). In comparison to acetaminophen, celecoxib appears to reduce pain and nausea after surgery better than the former. In many studies, celecoxib has not caused significant adverse effects, making it suitable as a preemptive medication to minimize lower extremity pain after surgery
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