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European journal of molecular biology and biochemistry

Volume 11, Issue 1, 2024
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
SERUM ENDOGLIN IN PREECLAMPSIA
Author
Potsangbam Jenny Devi1*, Sangeeta Naorem2, Racheal S Marbaniang1, Kshetrimayum Roshita Devi1, Medowelie Mathew1, Yanglem Ajitkumar3
Email
jane9pot@gmail.com
keyword
Endoglin, Preeclampsia, Homodimeric Transmembrane, Glycoprotein.
Abstract
Endoglin is a 180kDa homodimeric transmembrane glycoprotein consisting of 633 amino acids. It is a co-receptor of transforming growth factor TGF-?3. The soluble circulating form (sEng), cleared from membrane bound form (mEng) is an angiogenic factor, which was implicated in the pathogenesis of preeclampsia. Preeclampsia is characterized by high blood pressure (>140/90 mmHg), proteinuria (>300mg/day) after 20 weeks pregnancy in previously normotensive women. Aims and Objectives: To evaluate and compare the level of serum endoglin in preeclamptic women and healthy pregnant women and to correlate serum endoglin levels with blood pressure. Material and Methods: Study type: Case-control study conducted in the Department of Biochemistry and Department of Obstetrics and Gynaecology, RIMS Imphal Sample size: 30 preeclamtics and 30 healthy pregnant women admitted in antenatal ward, RIMS Study period:2 years Method: Serum Endoglin measured by ELISA method. Statistical analysis was done using SPSS version 21. P-value <0.05 was considered significant Results: Serum endoglin was found to be higher in cases(14.28±4.09) ng/ml than in controls (7.30±1.12)ng/ml. The levels were found to be positively correlated with both systolic and diastolic BP(r=0.819) and r=0.861 respectively) and were statistically significant(p=0.000) Conclusion: It was evident from the study that the mean serum endoglin levels were higher in preeclamptic women so it has the potential to be used as a new diagnostic biomarker of preeclampsia and as a predictor of disease severity
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