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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
CORNEAL SENSITIVITY TO TOPICAL NONSTEROIDAL ANTIINFLAMMATORY DRUGS IN TERMS OF MECHANICAL, CHEMICAL, AND THERMAL RESPONSES
Author
Gayathri U
Email
dr.u.gayathri@gmail.com
keyword
Corneal, Sensitivity, Mechanical, Chemical, Thermal
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are well known for their anti-inflammatory effects, but they also seem to have analgesic properties. Topical administration of commercial NSAIDs, diclofenac sodium and flurbiprofen, resulted in significant changes in threshold and intensity of sensations in humans. Gas esthesiometers were used to measure the corneal sensitivity of 5 healthy, young subjects. To stimulate the center of the cornea, a variety of stimuli were applied, including chemical, mechanical, and thermal ones. During the pulse, a continuous 10-cm visual analog scale (VAS) was used to determine the intensity and perceived magnitude of the evoked sensation. We determined the threshold by measuring the stimulus intensity that evoked a VAS score greater than 0.5. All subjects were tested on two separate days on their sensitivity to flurbiprofen (seven subjects) and diclofenac sodium (six subjects) 30 minutes after topical application. In a study of high-intensity mechanical, chemical, and thermal stimuli, diclofenac significantly attenuated all sensation parameters. The effects of flurbiprofen were only significant when it came to the irritation caused by the most intense chemical stimuli (70%CO2). The different stimuli's detection thresholds were not significantly changed by any of the drugs
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