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International Journal of Community Health Nursing

Volume 10, Issue 2, 2023
Mcmed International
International Journal of Community Health Nursing
Issn
XXX-XXXX (Print), XXXX-XXXX (Online)
Frequency
bi-annual
Email
editorijchn@mcmed.us
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Abstract
Title
WARFARIN AND PRESCRIPTIONS: ASSESSMENT OF POTENTIAL INTERACTIONS IN OUTPATIENTS AGED 45 AND OLDER
Author
Meruga Prashanthi*, Jarpala Rambabu, S Ujwala, Neelam Sreeja, Krupalini Vadapally
Email
prashanthi.pharmd1820@klr.ac.in
keyword
Warfarin, Outpatients, Prescriptions
Abstract
General practitioners prescribe warfarin for thromboembolic diseases prevention and treatment. Warfarin interactions with other drugs have not been systematically studied in outpatients to date. To determine whether there may be interactions between warfarin prescriptions and the rates of outpatients receiving the drug, we analyzed a cohort of outpatients receiving warfarin treatment. A retrospective study was conducted on 203,543 outpatients age 45 or older, of whom 7,074 were receiving warfarin therapy. A study analyzed patients who had taken more than one prescription medication concurrently with warfarin for at least 5 days. Stockley's Drug Interactions and domestic drug interaction databases were used to evaluate possible drug interactions in Epocrates online and Stockley's Drug Interactions. According to the study, patients taking warfarin concurrently used 4.7 drugs (SD=1.9) (males 4.7 SD=2.0, females 4.9 SD=2.0). Three-quarters of patients did not experience any interactions, 29% had at least one interaction, and 34% had two or more interactions. Men and women had about the same number of potential interactions on average. In general, there were more potential interactions with more drugs. More than half of the patients detected interactions related to warfarin, and 1 to 5 interactions were found per patient. Simvastatin (8%) and amiodarone (6%) were the drugs used most frequently with warfarin (15%). Among outpatients receiving warfarin, 58% have medications that could interact with warfarin. NSAID prescriptions account for most (15%) of interactions with warfarin
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