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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
METABOLIC SYNDROME, SKIN TAGS, LEPTIN AND LIFESTYLE CHANGE
Author
Ashwak Ahmed N1*, Praneeth N
Email
Ahmed@gmail.com
keyword
Skin Tags, hyperleptinemia, Leptin levels
Abstract
Most commonly, skin tags (STs) appear in middle-aged and elderly people's necks and axillae. Diabetes and cardiovascular disease are risk factors of metabolic syndrome (MS). There is a strong association between MS and hyperleptinaemia and leptin resistance in studies of different ethnic groups. The purpose of this study is to determine whether skin tags and leptin levels may be related to MS based on diagnostic criteria developed by the International Diabetes Federation (IDF). 80 participants were enrolled in this study, 40 of whom were ST patients and 40 of whom were apparently healthy controls. As well as triglycerides, cholesterol, HDL, criteria for MS, WC, BMI, fasting glucose levels, smoking status, insulin resistance, and insulin levels, all of these aspects were assessed. A univariate analysis revealed significant differences in WC, BMI, insulin resistance, fasting glucose, insulin levels, HDL, leptin levels, cholesterol and triglycerides between ST patients and controls (P 0.001). Among the MS components and ST, the multivariate analysis revealed only high triglyceride levels (OR 1.204/95% CI 1.043-1.392/P = 0.012) and low HDL levels (OR 0.553/95% CI 0.385-0.800/P = 0.003) were significantly associated with ST. High triglyceride levels were significantly associated with high plasma leptin levels when examining the predictors of high plasma leptin levels. The study indicates that ST patients may also have hyperleptinemia and high triglycerides, suggesting they may benefit from changing their lifestyle.
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