Acta Biomedica Scientia

AN ANALYSIS OF PROBLEMS RELATED TO SYMPTOMATIC THROMBOSIS CAUSED BY A CENTRAL VENOUS CATHETER HAS BEEN OBTAINED FROM A RETROSPECTIVE COHORT STUDY IN CRITICAL CARE UNIT INPATIENTS

Nandyala Sreekar1 & Kompella Sri Surya Gopinath

Nandyala@gmail.com

Thrombosis of the veins caused by catheters; symptoms; thromboembolism; dangerous state

A central venous catheter (CVC) is routinely used in critically ill patients for its ability to monitor vital signs, deliver drugs, and administer renal replacement therapy. CRVT is a condition caused by these catheters. We evaluated the rate of symptomatic CRVTs in ICU patients receiving CVCs along with disease-related risk factors that may contribute to symptomatic CRVT. From January 2015 to December 2019, 1643 consecutive patients who had CVC surgeries in the ICU were retrospectively examined. Sonography and clinical examination revealed many CRVT symptoms. From the electronic medical record system, the variables were retrieved and sorted into two groups based on the presence of symptomatic CRVT. We identified disease-related risk variables of CRVT using the logistic univariate and multivariate regression methods. Twenty-nine symptomatic CRVT events were recorded among the 2114 catheters. In 1000 catheter days, 9.5% of catheters experienced CRVT. The following factors have been identified as significant risk factors within the ICU for symptomatic CRVT: trauma, major surgery, heart failure, respiratory failure, and severe acute pancreatitis. In a multivariate analysis of the data, major surgery (OR 2.457; CI [1.641–3.679], P =.000), CRVT in the ICU (OR 2.087; CI [1.401–3.111], P =.000), and heart failure (OR 2.087; CI [1.401–3.111], P =.000) were all significant independent risk factors. This model was statistically significant with a C-statistic of 0.61 (95 percent confidence interval [0.57-0.65], P = 0.000). It was estimated that 9.5 catheter days per 1000 were symptomatic in the ICU group. There is a link between trauma, major surgery, and heart failure and symptoms of CRVT because all three are risk factors for the disease