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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
SNAP (S-NITROSO-N-ACETYL PENICILLAMINE) HAS LONGTERM BIOCOMPATIBILITY THROUGH COVALENT IMMOBILIZATION AND EXHIBITS SUSTAINED NITRIC OXIDE RELEASE FOR 4 MONTHS
Author
Dr. Parija Jyothi Prakash
Email
drvrvkk@gmail.com
keyword
S-nitroso-N-acetyl penicillamine, Intercorporeal circulation, bioreactor, antimicrobial, biocompatible
Abstract
Over the past three decades, researchers have developed a variety of NO-releasing polymeric materials after discovering the importance of endogenous nitric oxide in regulating a wide range of biological processes. Almost all of these materials have short lifespans because NO donor molecules are poorly incorporated into the polymer matrix. To develop a stable material that releases nitric oxide (NO), S-nitroso-N-acetylpenicillamine (SNAP) was combined with polydimethylsiloxane (PDMS). No NO donor can be leached into the environment because SNAP is anchored to the PDMS crosslinker. It has been the first time that a NO-releasing polymer has been able to continue releasing NO and suppressing bacteria over this period, indicating that it may have long-term hemocompatibility and biocompatibility. By demonstrating a 99.99 percent reduction in a continuous flow CDC bioreactor after three days and a 99.50 percent inhibitory potential after a month, the material shows excellent antibacterial activity against Staphylococcus aureus. A rabbit extracorporeal circuit (ECC) model was used to test SNAP-hemocompatibility PDMS's during a 4-hour period. When compared to the control circuits, thrombus growth was dramatically reduced in the SNAP-PDMS coated ECCs, The overall thrombus mass was reduced by 78 percent. This material may prove useful for long-term clinical applications for biomedical devices in contact with blood and tissues when infection and unwanted clotting are significant concerns
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