European journal of molecular biology and biochemistry

EVALUATION OF THE BIOCHEMICAL PARAMETERS AND TREATMENT OF ACUTE PROSTATIC HAEMATURIA WITH DUTASTERIDE

Dr.Lal Bahadur Sastri1, Dr.Siva kumar

Sivakumar@gmail.com

Acute Prostatic Haematuria, Dutasteride.

After transurethral prostate excision, dutasteride has been demonstrated to minimise chronic prostatic haemorrhage when given 2-6 weeks before the surgery. Acute gross prostatic haematuria is being studied to see whether the medicine has any impact on it. Patients and Methods: Patients with repeated episodes of severe haemorrhage were included. All three tests were performed in order to rule out the possibility of haematuria being caused by medical, renal, or bladder issues. Those suspected of having prostatic haematuria were subsequently investigated utilising a blood PSA and a Prostate Scan. Prostate biopsy was performed on those who had a PSA level more than or equal to 10 ng/ml and a negative digital rectal examination (DRE). There were two groups of patients. Dutasteride was given to the second group, whereas the control group was given normal saline and broad-spectrum antibiotics. After the haematuria subsided, we kept note of how long it took and how much irrigation fluid we used. SPSS 20.0 was used for the statistical analysis. Prostatic haematuria was discovered in a total of 75 individuals. Sixty-five percent had BPH and thirty-six percent had cancer of the prostate. An additional oral dutaste-ride was given to 24 of the 49 BPH patients (49 percent), while usual saline irrigation and antibiotics were administered to 25 (51%). Most patients received saline drainage and antibiotics, but only a small percentage received dutasteride as an extra therapy. As compared to the control medication, dutasteride was able to eliminate haematuria more quickly and with less irrigation fluid than the former. Prostatic haematuria may be cured more quickly with the increment of 0.5 mg of orally dutasteride per day