American Journal of Oral Medicine and Radiology

ESTIMATION AND COMPARISION OF SERUM VITAMIN C, VITAMIN E AND REDUCED GLUTATHIONE LEVELS IN ORAL SUBMUCOUS FIBROSIS PATIENTS AND CONTROLS - A STUDY

Swathy D

Swathy@gmail.com

Serum Vitamin-C, Vitamin -E, oral sub mucous fibrosis patients, reduced glutathione

Oral submucous fibrosis is a common precancerous condition. The primary factor considered in the etiology of OSMF is the habitual use of betel nut and its commercial preparations which generates high levels of reactive oxygen species (ROS). However, several other factors are believed to contribute to the development of OSMF including nutritional and vitamin deficiencies. Aim and objectives: The aim of the study is to evaluate the role of non-enzymatic antioxidants like vitamin C, vitamin E and reduced glutathione in Oral Submucous Fibrosis (OSMF) and thus to evaluate, whether the above antioxidants can be used as a biomarker for the progression of the diseases. Materials and method: For our study 30 newly diagnosed OSMF patients of both sex with age group between 20 to 60 years and the same number of age and sex matched healthy individuals were selected as control group. In both the groups, serum vitamin C, E and reduced glutathione were assessed. Results: The values between serum vitamin C, vitamin E and reduced glutathione in between OSMF patients and healthy groups (n = 50) were statistically significant with P value <0.001. The values of the parameters were decreased with the progression of the duration of habits with the P value of 0.375, 0.081, and 0.204 (not statistically significant) for reduced glutathione, vitamin C and vitamin E. The ROC analysis curve showed 100% diagnostic accuracy for reduced glutathione than vitamin C and E. Conclusion: This study suggests that antioxidants play an important role in OSMF and its progression and very low levels of non-enzymatic antioxidants, thus creating oxidative stress, which might be playing an important role in OSMF and its or transforming OSMF into malignant condition