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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
OUTCOME OF INTRAOPERATIVE DEXMEDETOMIDINE ON POST-OPERATIVE COGNITIVE DYSFUNCTION OF AGED PATIENTS UNDER GOING LARYNX SURGERY
Author
Rajeswaran S, 2Ravichandran S
Email
dr.s.ravichand@gmail.com
keyword
Post-operative cognitive dysfunction, Dexmedetomidine, Sedation, Sevoflurane
Abstract
Postoperative Cognitive Dysfunction (POCD) is one of the most common complications affecting the central nervous system after general anaesthesia and surgery especially in elderly patients. It’s characterized by short-term cognitive decline and includes memory, mood, confusion, and sleep disorders. Its medical manifestations include cognitive disorder, personality exchange and memory loss, intellectual problems and social impairment. Starting with demographic data, the mean age of the included cases was 69.98 and 70.02 years in the Dex and control groups, respectively. Males represented the majority of the included cases, as they formed 100 and 98.9% of cases in the same groups, respectively. Body mass index (BMI) had mean values of 28.11 and 27.43kg/m2 in the two groups, respectively. Dexmedetomidine administration is related with a considerable development of cognitive function after surgery in the elderly patients. It is linked with a better analgesic and sedative profile and decreased neurological inflammatory markers (S100B). Conversely, we should closely monitor for the side effects like bradycardia and hypotension in these patients
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