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Acta Biomedica Scientia

Volume 1, Issue 2, 2013
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
ANTI-DIABETIC AND HYPOLIPIDAMIC EFFECTS OF Costus igneus LEAVES EXTRACTS AGAINST STREPTOZOTOCIN INDUCED DIABETIC ALBINO RATS
Author
N.Kanivalan1, R.Rajakumar1, P.Mani2*
Email
master.maniji@gmail.com
keyword
Costus igneus, Diabetic, Streptozotocin, Lipid profile, Glucose.
Abstract
The present study investigates the antidiabetic effect of leaf extract of Costus igneus on Streptozotocin (STZ) diabetic rats. The rats treated with Streptozotocin showed a significant increased in glucose level and altered level of lipid profile, heamoglobin and insulin were observed. The mechanism underlying STZ hyperglycemia in diabetes mellitus involves over-production (excessive hepatic glycogenolysis and gluconeogenesis) and decreased utilization of glucose by the tissues. Twenty-eight days administration of ethanolic extract of leaf of the Costus igneus (200 and 300mg/kg b.wt.) to diabetic ratsresulted in significant reduction in blood glucose level, restored heamoglobin, lipid profile and insulin as compared to diabetic rats. The present study suggests that the Costus igneus leaves extracts had synergetic hypoglycemic effect revealed by decreased serum lipid levels, restored insulin, heamoglobin and therefore attribute to therapeutic value of the Costus igneus extracts of leaves to combat the diabetic condition in rats. Among the two doses, 300mg/kg of Costus igneus leaves extract possess potential anti-diabetic activity.
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