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European journal of molecular biology and biochemistry

Volume 11, Issue 1, 2024
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
ANTISICKLING POTENTIAL OF THE ETHANOLIC FLOWER EXTRACTS OF COUROUPITA GUIANENSIS
Author
G.Sandhyarani1 and K.Praveen Kumar2
Email
sandhyaguggilla9@gmail.com
keyword
Sickle Cell Disease,polymerization, Antisickling, Sickling Reversal.
Abstract
This work was therefore aimed at investigating the Antisickling potential of the ethanol seed extract of Couroupitaguianensis used as a traditional herbal medicine with a view of proposing an effective herbal recipe for the management of sickle cell disease. Preliminary phytochemistry, sickling inhibition test, sickling reversal test and polymerization test were carried out using standard methods. The phytochemical analysis indicated the presence of saponins, reducing sugar, carbohydrate, fats and oil, steroids, glycosides, alkaloids. The results of the antisickling test showed significantly (p<0.05) higher antisickling effect. The percentage sickling reversal effect was significantly higher than the control. The result of the polymerization showed that ethanolic extract significantly (p<0.05) increased delayed time before polymerization at 50, 25 and 12% concentrations compared to the control. From the results, the extract have shown to be therapeutically beneficial in the management of sickle cell disease and thus are strongly recommended by this study to be developed into supplements for the management of sickle cell disease.
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