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American Journal of Biological and Pharmaceutical Research

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
IN-VIVO SCREENING OF TINOSPORA SINENSIS LEAVES FOR ITS ANALGESIC, ANTI-PYRETICAND ANTI-INFLAMMATORY ACTIVITIES
Author
Aruna Devi M*, Durga Prasad B,Parameshwar P
Email
drarunadevi.tcps@gmail.com
keyword
Tinospora sinensis leaves, Analgesic, Anti-inflammatory, Anti-pyretic.
Abstract
Previous phytochemical analysis of methanolic extract of Tinospora sinensis leaves (METS) has indicated the presence of steroids, flavonoids, glycosides and terpenoid types of compounds. Since these compounds are of pharmacological interest, coupled with the use of this plant in traditional medicine, prompted us to check Tinospora sinensis leaves for possible analgesic anti-inflammatory and anti-pyretic activities. The analgesic activity of METS was studied using tail immersion method in mice. While the efficacy of the METS (150 and 300mg/kg.p.o) was compared with pentazocaine 30 mg/kg. METS recorded 79.88 % inhibition with the highest dose and 81.21% with pentazocaine. The antipyretic activity of METS was studied in Brewer’s yeast-induced pyrexia in rats. METS showed more significant activity. METS were also subjected to evaluate anti-inflammatory activity by carrageenan induced rat paw edema. Indomethacin (100mg/kg) was taken as standard drug. METS produced dose-dependent of oedema, which was comparable to Indomethacin and found to be 48.32% and 42.32 % inhibition in carrageenan induced rat paw edema model. Findings from the present study showed METS to possess central and peripheral analgesic activity, anti-inflammatory property similar to steroidal and non-steroidal agents as well as antipyretic effect.
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