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American Journal of Biological and Pharmaceutical Research

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
STUDY OF ANTIMICROBIAL PROPERTIES OF TINOSPORA SINENSIS BY AGAR WELL DIFFUSION METHOD
Author
Mahesh Aruna Devi*, Beda Durga Prasad, BarlaRambabu
Email
drarunadevi.tcps@gmail.com
keyword
Tinospora sinensis, Antimicrobial activity, Ethanolic, methanolic, Aqueous and chloroform extracts.
Abstract
Antimicrobial activity of ethanolic, methanolic, aqueous and chloroform extracts of leaves, stems and flowers of Tinospora sinensis were studied against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Aspergillus niger and Aspergillus fumigatusby agar well diffusion method. Ethanolic leaf extract of Tinospora sinensis had shown antimicrobial activity against Candida albican, Pseudomonas aeruginosa, and Aspergillus niger (with zone of inhibition 14, 13 & 8 mm respectively). Ethanolic stem and flower extract had shown antimicrobial activity against Staphylococcus aureus and Aspergillus niger (with zone of inhibition 19, 6 mm by stem extract and 8, 10 mm by flower extract). Maximum antifungal activity against Candida albicans was exhibited by methanolic flower extract of Tinospora sinensis (18 mm zone of inhibition) followed by methanolic leaf extract (13 mm zone of inhibition) and then methanolic stem extract (11mm zone of inhibition). Chloroform flower extract of Tinospora sinensis had shown antibacterial activity against gram negative bacteria Pseudomonas aeruginosa (with zone of inhibition 4 mm). Aqueous leaves stem and flower extract of Tinospora sinensis were not effective against any bacterial and fungal strains. Hence the ethanolic extract is more useful for preparing the antibacterial drugs while methanolic extracts are useful for antifungal extract. Present study concludes that antimicrobial activity against selected strains varies among the different plant parts used and depends largely upon the extraction procedure, type of solvent used for extraction, and the bacterial strains tested.
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