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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
SERUM URIC ACID LEVELS IN CHRONIC KIDNEY DISEASE PATIENTS IN INDIANS
Author
K. Narayanan, S. Raja, E.Prabhakar Reddy
Email
drpebyreddy@gmail.com
keyword
Uric acid; Biomarker, Chronic kidney disease, Epidemiology
Abstract
Both serum uric acid (SUA) and chronic kidney disease (CKD) are associated with the risk of cardiovascular disease. Hyperuricemia has been attracting attention at the clinical level as a risk factor for the progression of kidney dysfunction. Several epidemiological studies have demonstrated as association between higher serum uric acid (SUA) levels and greater risk of CKD incidence. Hyperuricemia probably causes kidney damage by a mechanism involving systemic and glomerular hypertension. Tubulointerstitial fibrosis, which might be readily associated to the direct proinflammatory effects of soluble urate, is independent from the precipitation of monosodium urate crystals in the kidney. In CKD patients, higher serum uric acid levels are associated with higher degree of renal dysfunction, hypertension, diabetes, dyslipidemia, smoking, CRP, urine albuminuria,anaemia, cardiovascular disease/ events and mortality. The most common cause of mortality in ckd patients with raised serum uric acid was cardiovascular disease/ events
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