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American Journal of Biological and Pharmaceutical Research

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
OPTIMIZATION OF PRODUCT AND PROCESS VARIABLE IN FORMULATION OF ISONIAZID SLN NANOPARTICLE
Author
K. Shahul Hameed Maraicar, Sunil Kumar Prajapati, Thirumoorthy Narayanan
Email
kemisha2002@yahoo.co.in
keyword
Isoniazid, SLN, Zeta Size, PDI, Particle size etc.
Abstract
The Aim of current study is to select optimized method for design of Solid Lipid Nanoparticle. The objective of the study is to optimize the solvent evaporation method for the preparation of Solid Lipid Nanoparticle by altering the product and process variable in the formulation. Here the independent product variable is surfactant and the dependent process variable is homogenization and ultrasonication. And then by varying this both independent and dependent variables Isoniazid SLN was formulated by using solvent evaporation method in order to decrease the dose, adverse effects and targeting effect. Evaluation variables like Particle size, Poly dispersibility index (PDI) and Zeta-potential are carried out by Malvern Zeta sizer. By the current results it was concluded that the optimized product and process variables that shown in the results are needed for the best formulation development technique for Isoniazid SLN.
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