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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
A CASE STUDY ON RETINOID INDUCED DARIER’S DISEASE
Author
Sai Harshitha K B1*, Likitha B S V V1, Mahima M S1, Sai Aswani V1
Email
saiharshitha8594@gmail.com
keyword
Darier’s Disease, Dermal Infections, Retinoid, Adverse Drug Reaction
Abstract
Darier’s disease is a rare cutaneous disease with an autosomal dominant mode of inheritance. Greasy papules and plaques arise on the seborrheic areas and in the flexures and almost all patients have nail abnormalities. Darier’s disease is an example of a dominantly inherited disease caused by haplo-insufficiency. Oral retinoids are the most effective treatment but their adverse effects are troublesome. Topical retinoids, topical corticosteroids, surgery, and laser surgery have their advocates but evidence for efficacy is sparse. Pre?therapy investigations of cell?mediated immunity showed no severe immunological dysfunction, although high responses to supra?optimal Con A concentrations suggested abnormalities in immunoregulatory lymphocyte subpopulations. In addition, patients showed enhanced LMIF production upon stimulation with Con A, PWM and PPD. Retinoid therapy decreased the number of peripheral blood total leukocytes, lymphocytes and T?cells, normalized the LMIF production, and decreased the lymphocyte responses to mitogens.
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