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Acta Biomedica Scientia

Volume 1, Issue 2, 2013
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
STEVENS–JOHNSON SYNDROME ASSOCIATED WITH VALPROIC ACID: A CASE REPORT
Author
S.Vijaya Kumar1,*, P.Alekhya2, Ramchandra Dharak3
Email
vijayvijay66@yahoo.co.in
keyword
Sodium valporate, Skin rashes, Epilepsy, dermatology and Limbs.
Abstract
Stevens-Johnson syndrome (SJS) is a rare vesiculobullous disease of the skin and mucosa. Without proper management, it can be life threatening. Very strong associations of sodium valporate –induced SJS werereported in this case report. Medical history revealed that SJS developed following a change in medication for epilepsy from phenytoin to valproic acid (300 mg bid) by a local physician. Our authors suggested that, to overcome this problem, early diagnosis and implementation of interdisciplinary approach for management of SJS and careful monitoring for complications with regards to morbidity and mortality of life threatening cutaneous disorders. This report should alert the physicians to this severe cutaneous reaction of valproic acid.
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