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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
FORMULATION OPTIMIZING OF TERBINATINE TABLETS
Author
Ramesh M*, C.R Akila, M.Purushothaman, Vincent Vidyasagar Jenugu, Gadapuram Tharunkumar
Email
shreeramesh@gmail.com
keyword
Terbinatine, Floating, Tablets, HPMC.
Abstract
Gastric emptying is the process by which the stomach contents are moved to duodenum and shows prolongation ability. It measures the time it take for food to empty stomach and to reach small intestine. Controlled release system shows number of difficulties to produce better absorption and enhancement of bioavailability. The inability of dosage form in GIT is the most difficult form. Dosage form prolongs the gastric retention during drug absorption time and then improving bioavailability, decreases wasting of drug and increases drug solubility that is lesser soluble in high PH environment. Terbinatineis and antifungal drug that is used to treat cancdidiasis. This study observed that the Terbinatine formulation shows gastro retentive DDS in floating tablet form with the use of polymers, HPMC 4M, HPMC 15M & HPMC 100M & other excipients in various ratios and are evaluated. From the study it is evident that a promising controlled release by floating tablets of Terbinatine can be developed using HPMC polymer and Sodium bicarbonate. All the formulations showed good buoyancy and drug release. It is clear that drug release from the tablets is dependent on the polymer concentration, swelling properties, and dimensions of the tablet
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