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American Journal of Biological and Pharmaceutical Research

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
ANTI-CONVULSION ACTIVITY OF DOLICHANDRONE FALCATA ON PENTYLENETETRAZOLE (PTZ) INDUCED SEIZURES MODEL
Author
Eidan Musa Al Zahrani*, A.Zechariah Jebakumar1, Hassan S. Nondo1, Vadivel Kannan3
Email
edanma@hotmail.com
keyword
Anti-convulsion activity, Dolichandronefalcata, Pentylenetetrazole (PTZ).
Abstract
Investigation of anti-convulsion activity of aqueous extract of Dolichandronefalcata (AEDF) in Pentylenetetrazole (PTZ) induced seizures model in albino wistar rats. Acute toxicity of extract was non toxic up to the recommended dose 2000 mg/kg. p.o. Animals were treated with AEDF at doses of 200 and 400 mg/kg body weight. In Pentylenetetrazol induced seizure model, onset of myoclonic spasm and clonic convulsion was delayed in the AEDF treated groups. AEDF showed anti-convulsion activity against PTZ animal model. However, further studies still needed to be carried on exposure of the extract to humans.
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