European journal of molecular biology and biochemistry

AN ELEVATED FERRITIN LEVEL IS AN INDICATOR TO IDENTIFY METABOLIC SYNDROME AND INSULIN RESISTANCE IN IMPAIRED FASTING GLUCOSE SUBJECTS

Dr. Boinapalli sudhakar, Dr. JJJ Fallerio, Dr. RM Shah

boinapallisudhakar@gmail.com

serum ferritin, metabolic syndrome, insulin resistance, fasting glucose. ABSTRACT The main aim of this study to find out elevated serum ferritin relates the risk of metabolic syndrome and insulin resistance in healthy participants and impaired fasting gl

The main aim of this study to find out elevated serum ferritin relates the risk of metabolic syndrome and insulin resistance in healthy participants and impaired fasting glucose respondents. Methods: In this study the participants are categorized in to two groups based up on the fasting blood glucose levels. Group 1 healthy participant those are visiting from factories, police, and army camps to Dhiraj Hospital as part of company health scheme for routine checkup and found to have no disease or fasting glucose levels below 100 mg/dl considered as healthy or control subjects. Group 2 impaired fasting glucose respondents whose fasting blood glucose lies between 100-125 mg/dl (5.6-7.00 mmol/l). This study included 219 respondents with impaired fasting glucose levels and 378 healthy participants. Total number of participants included 607 from period August 2011 to March 2015. Serum ferritin levels, fasting plasma glucose, serum insulins levels, glycosylated hemoglobin levels, fasting lipid profile levels, components of metabolic syndrome (measurement of BMI, waist: hip circumference ratio, measuring blood pressure and estimating blood triglyceride, HDL-Cholesterol levels) and insulin resistance markers homeostasis Model Assessment-insulin resistance (HOMA-IR), were calculated by measuring fasting insulin and glucose levels. The present study was restricted to participant?s women who were not pregnant at the time of examination. In this study participants who fasted <8 hrs at the time of examination are excluded. Results: The more number of respondents with elevated ferritin in impaired fasting glucose group (men: 24.21%; women: 27.57%). The odd ratio for men 5.59 (95% CI: 2.8519-10.968) and women 4.88(95% CI: 2.158-11.0747) in percentage of individuals with elevated ferritin in impaired fasting glucose respondents. Conclusion: This study reveals an elevated serum ferritin levels indicates more chances for developing insulin resistance syndrome and metabolic syndrome in adults.