American Journal of Biological and Pharmaceutical Research

EVALUATION OF ANTI-PARKINSONIAN EFFECTS OF ETHANOLIC EXTRACT OF RHUBARB (Rheum Emodin) IN RATS

Anjali M.Wankhade*, Pooja R. Ganeshkar, Akash V. Lohar

anjaliwankhade@yahoo.com

Behavioral parameters, Rhubarb (rheum emodin), haloperidol, parkinsonian disease

Rhubarb (Da Huang) is dried rhizomes and roots of Rhubarb palmatum L, Rheum tangguticum Maxim. ex Balf, or Rheum officinale Baill from Polygonaceae family Rhubarb is a well-known traditional Chinese medicine; it has been used in China for thousands of years. Rhubarb anthraquinones are the major medicinal ingredients derived from rhubarb including emodin, aloe-emodin, chrysophanol, rhein, physcion, and danthron. These different anthraquinone derivatives alone or in combination play a therapeutic role in central nervous system diseases (CNSD), such as cerebral ischemic stroke, intracerebral hemorrhage, traumatic brain injury, brain tumor, Alzheimer‘s disease, depression, and others Modern pharmacological studies indicated that these anthraquinones possess a wide spectrum of pharmacological properties, such as anti-infammatory, antioxidant, antitumor, and antivirus. Results: In groups treated with ethanolic extract of Rhubarb (rheum emodin) 200 and 400mg/kg p.o.,) The anti?oxidative properties of EERE reduced the duration of the catalepsy and increased the locomotor activity along with motor coordination. The group treated with EERE 400 mg/kg showed normal locomotor activity and motor coordination without any cataleptic behavior when compared with haloperidol?treated group. Conclusion: In this research, the animals which were treated for 14 days with haloperidol showed severe cataleptic responses along with decreased locomotor and motor coordination. The anti?oxidative properties of EERE reduced the duration of the catalepsy and increased the locomotor activity along with motor coordination. The group treated with EERE 400 mg/kg showed normal locomotor activity and motor coordination without any cataleptic behavior when compared with haloperidol?treated group. The group treated with EERE 100, 200 mg/kg showed some cataleptic behavior when compared to EERE 400 mg/kg treated group.