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Acta Biomedica Scientia

Volume 1, Issue 2, 2013
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
ANTIULCER EFFECTS OF AQUEOUS EXTRACTS OF STEM-BARK OF DOLICHANDRONE FALCATA (AEDF) AGAINST ASPIRIN-INDUCED ULCEROGENESIS IN RATS
Author
A.ZechariahJebakumar*1, Hassan S. Nondo1, Eidan Musa Al Zahrani2,Vadivel Kannan3
Email
zacbiostat@gmail.com
keyword
Dolichandrone falcate, Aspirin, Anti-secretory, Anti-ulcerogenic.
Abstract
The study aimed to investigate the mechanism underlying theantiulcer effects of aqueous extracts of stem-bark of Dolichandrone falcate (AEDF) against aspirin-induced ulcerogenesis in rats. Acute gastric ulcer was induced by orally administering 200 mg/kg aspirin suspended in 1%v/v tween 80solution in rats.The volumes of the gastric content, pH, total & free acidity of gastric juice weremeasured and ulcer index &percentage of ulcer protection were calculated.The present results suggested that Dolichandronefalcatadecreased ulcer index and increased percentage of ulcer protection by significant reduction of volume of the gastric content, total & free acidity of gastric juice inversely increases the pH. This effect may protect the gastric mucosa against ulceration by antisecretory and antiulcerogenic property of Dolichandrone falcate.
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