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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
A COMPARATIVE STUDY OF ANTINOCICEPTIVE ACTIVITY OF FLUPIRTINE WITH DICLOFENAC IN SWISS ALBINO MICE
Author
Mishra AK, Sinha RR, Tiwari RK, Dhone PG, Hishikar R, Rathod V
Email
pravin.dhone@yahoo.com.
keyword
Analgesia, Flupirtine, Diclofenac, Opioids
Abstract
There is a need for new effective analgesic drugs with fewer side effects and minimum drug abuse liability. Flupirtine is a centrally acting, non-opioid analgesic agent with unique pharmacological properties. Materials and Methods: Tail flick (thermal method), tail clip (physical method) and writhing test (chemical method) were used as in-vivo model. Flupirtine (10 and 20 mg/kg i.p.) was administered as test drug in mice and compared with diclofenac (10 mg/kg i.p.) as standard drug. The analgesic activity was studied by recording the reaction time after administration of the drug at frequent intervals up to 90 minutes. The results were analyzed by ANOVA and Bonferroni’s test. P value < 0.05 was considered as significant. Results: Administration of flupirtine showed significant increase in reaction time as compared to control at all the time intervals. Flupirtine inhibited the nociceptive responses induced by chemical, thermal and mechanical stimuli in rodents. Conclusion: Flupirtine has good analgesic activity in this experimental model of pain
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