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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
EXPERIMENTAL EVALUATION OF ANALGESIC ACTIVITY OF FLUPIRTINE WITH OPIOIDS ON SWISS ALBINO MICE
Author
Mishra AK, Sinha RR, Tiwari RK, Dhone PG, Hishikar R, Rathod V
Email
pravin.dhone@yahoo.com
keyword
Analgesia, Flupirtine, Pentazocine, Tramadol
Abstract
There is a need for new effective analgesic drugs with fewer side effects and minimum drug abuse liability. Flupirtine is a centrally acting, non-opioid analgesic agent with unique pharmacological properties. Materials and Methods: Tail flick (thermal method) and tail clip (physical method) were used as in-vivo model. Flupirtine (10 and 20 mg/kg i.p.) was administered as test drug in mice and compared with Pentazocine and tramadol (10 mg/kg i.p.) as standard drugs. The analgesic activity was studied by recording the reaction time after administration of the drug at frequent intervals up to 90 minutes. The results were analyzed by ANOVA and Bonferroni?s test. P value < 0.05 was considered as significant. Results: Administration of flupirtine showed significant increase in reaction time as compared to control. Flupirtine inhibited the nociceptive responses induced by thermal and mechanical stimuli in rodents. Conclusion: Flupirtine has comparable analgesic activity with opioids in this experimental model of pain
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