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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
LIQUID PROFILING: A NOVEL PANEL FOR CANCER DETECTION, CURE AND THERAPEUTIC RESISTANCE
Author
Dr. Boinapalli Sudhakar and Dr. Deepthi Rao
Email
boinapallisudhakar@gmail.com
keyword
LIQUID PROFILING
Abstract
In future tumor DNA and tumor cells in circulating fluids plays crucial cancer marker in field of cancer diagnosis and therapy. The genotyping of somatic genetic alterations reveals more informative about tumor progress but has limitations. A liquid profile of circulating nucleic acids is a less painful procedure substitute with surgical biopsies of solid tissues, usually obtained through the extraction of a blood sample or other body fluids. Cell free genetic fragments are released into the blood circulation by all nucleated cells through process apoptosis or necrosis, and amount of circulating cell-free DNA (cfDNA) correlates with various levels of tumor and its prognosis. Fortunately ctDNA frequently signifies a small fraction (1.0%) of total cfDNA. ctDNA differentiated from normal DNA in presence of altered sequence. Moreover the ctDNAs identification shows mainly tumor-related genetic and epigenetic variations. Circulating tumor cells (CTC) in blood sample makes us to known number of cancer related phenomenon, but not limited to the presence of mutations, loss of heterozygosity, gene over expression, alternative splicing, drug sensitivity and resistance. This review illustrate about circulating tumor DNA and tumor cells in diagnostic perspective and presents on existing challenges of cancer diagnosis, cure, and drug resistance.
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