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European journal of molecular biology and biochemistry

Volume 6, Issue 1, 2019
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
SERUM N-ACETYL-BETA-GLUCOSAMINIDASE LEVEL IN DIABETES MELLITUS
Author
Davina Hijam*, Sonam Tashi Dolma, Wahengbam Diana Devi, Prabita Oinam
Email
davina_hijam@yahoo.co.in
keyword
Diabetes, N-Acetyl ?- Glucosaminidase, Blood sugar, Complication.
Abstract
Lysosomal enzyme beta-n-acetyl-glucosaminidase (NAG) show an increase in diabetes mellitus and this is closely related to diabetic metabolic alterations. To estimate serum NAG levels in diabetic patients (with and without complications) and to compare the levels with that of controls. This was a cross- sectional study conducted on 50 diabetic subjects (Group A - 25 patients without complications and Group B - 25 patients with complications) in RIMS hospital during the period from September 2016 to August 2018. Twenty five age and sex matched healthy individual were taken as controls. Glycosylated haemoglobin (HbA1c) was estimated by Fast Ion Exchange Resin Method. Serum NAG was estimated by Sandwich ELISA. The difference in the level of fasting blood sugar (FBS), postprandial blood sugar (PPBS) and glycosylated haemoglobin (HbA1c) between control and diabetic groups (A and B) was statistically significant (P<0.001) indicating a poor control of diabetes in the study group. There was a significant difference in the level of NAG in control, group A and group B (11±2.9, 26.36±5.41 and74.87±24.55)U/L respectively. The comparison of serum NAG in male and female subjects in the study groups was insignificant. Statistically significant increase in serum NAG level was observed in group B compared to group A (p <0.001). There was a significant positive correlation of serum NAG with FBS, PPBS and HbA1c. Serum NAG can be used as an index for the development and prognosis of diabetic complications.
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