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American Journal of Biological and Pharmaceutical Research

Volume 7, Issue 2, 2020
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
ANTIDIABETIC ACTION OF SULPHONAMIDE DERIVATIVES:A REVIEW
Author
Shefanath1, Anagha. C. M., Sherin A, Shiji Kumar PS
Email
anaghachandran2@gmail.com
keyword
Diabetic mellitus, Pharmacological treatment, Sulphonamides, Sulphonylurea.
Abstract
Diabetic mellitus is a metabolic disorder which can be characterized by the hyperglycemic resulting from defect in the insulin secretion. Diabetic mellitus are of two types; insulin dependent and non- insulin dependent. Most commonly found diabetic mellitus is a non- insulin diabetic mellitus, which are characterized by destruction of pancreatic cell or decrease insulin secretion. There are many pharmacological and non-pharmacological treatments. Pharmacological treatment includes sulfonamides and biguanides that can be used to reduce the hyperglycemic effect. Sulfonamides are known as sulfa drugs. Sulfonamide that have the sulfonamide moiety of S02NH2 have which are responsible for the various pharmacological action like hypoglycemic ,antivirus, antibacterial, anti- carbonic anhydrous, ant thyroid activity. But sulfonamidehas more anti-diabetic action and their derivatives like sulphonulurea stimulates insulin secretion from the beta cell of the pancreas and that associated with hyperglycemic and weight gain. These include drug such as tolbutamide and glibenclamide. It concluded that, the sulphonamide derivatives show useful results for hypoglycemic activity compared to that of the control and standard respectively. This review highlights antidiabetic activity of sulphonamide derivatives.
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