International Journal of Advances In Case Reports

ISONIAZID PREVENTIVE THERAPY UTILIZATION RATE AND ASSOCIATED FACTORS IN ADULT HIV/AIDS PATIENTS IN JIMMA UNIVERSITY SPECIALIZED HOSPITAL ART CLINIC: A CROSSSECTIONAL STUDY

Gudeta Imana, Vinodhini Rajamanickam and Kifle Woldemichael

gudetaim2013@gmail.com

IPT, TB /HIV, PLHIV, ART, INH prophylaxis

Tuberculosis (TB) is the most frequent life-threatening infection and a common cause of death for people living with HIV (PLHIV). The influence of TB and HIV infection has enhanced the magnitude of both epidemics. IPT is one of the key interventions recommended by the world health organization (WHO) for the prevention of TB in patients infected with HIV. Hence the present study includes quantitative investigation that aimed to determine IPT utilization rate among adult HIV infected patients enrolled in HIV care and qualitative analysis which explore the factors that influence IPT use among PLHIV under follow-up, Health care providers (HCP’s) and TB/HIV coordinators working in Jimma University Specialized Hospital (JUSH) ART clinic, Ethiopia. An Institution based mixed cross-sectional study was conducted in JUSH ART clinic, Oromia region, Ethiopia. Adult HIV infected patients were registered and enrolled by a systematic sampling technique from the registered medical records of JUSH HIV care. PLHIV who were on follow-up during the study period, permanent HCP’s and TB/HIV coordinators working in ART clinic, who showed voluntary participation for semi-structured questioners and in-depth interviews were included in the quantitative investigation. All statistical analysis was compiled by Epidata 3.1 and SPSS 20. Demographic and clinical factors are not significant in PLHIV, but ethnicity (P ≤ 0.02**) was highly significant with IPT use in binary logistic regression model. With regard to IPT use, 59.2% of the patients have been prescribed and taken at least onemonth course of IPT while 40.8% have not been taken IPT. Adult HIV infected patients eligible for IPT prescription, HCP’s and TB/HIV coordinators were interviewed on identifying the factors and barriers that increase the utilization of IPT. The results of in-depth interviews are grouped into three core categories as patient perceptions, HCP’s and TB/HIV coordinator perspectives. PLHIV, HCP’s and TB/HIV coordinators suggested their overall response as periodic counseling for target groups, educating the benefits of IPT and increasing public awareness on TB prophylaxis in PLHIV. Higher attention should be provided in linking all HIV patients to the nearest health facilities for receiving free service packages and medical care.